Project Title: Understanding CXCR4 Activation and its Signaling Network Through the Integration of Structural, Functional and Computational Approaches
CXCR4 is a key receptor in the proliferation of most cancers, and is a key therapeutic target. Here we plan to determine the structure of an active ternary complex of CXCR4, bound to heterotrimeric G protein. Understanding CXCR4 structure, and signaling mechanisms will facilitate the design of therapeutics targeting the receptor, or other downstream molecules.
Mentors: Drs. Tracy Handel and Irina Kufareva, UC San Diego